Twin-Screw Granulator for the pharmaceutical industry
Twin-Screw Granulator - BCG
Twin-screw pelletising has been an established method for continuous wet pelletising since the early 2000s. Twin screw pelletising is a fully continuous process by design and can be seen as a starting point for companies to begin continuous production of pharmaceuticals.
More about the highlights
The Twin-Screw Granulator BCG can be operated alone or fully integrated into the continuous production line QbCon® from L.B. Bohle.
The powder to be granulated is fed onto two so-called screws, which rotate in the same direction in a cylinder, thereby transporting the material through the process zone and kneading and mixing it at the same time. The flexible design of the screws enables the production of granulates with different porosities that meet all the requirements of downstream drying and tableting.
Twin-Screw Granulator BCG -
The advantages
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Short dwell times of the material in the process (< 1 min - a few seconds)
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Fast and efficient reactions to process and quality deviations
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Reduction of the space required for the machines and the associated GMP areas
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This eliminates the need to increase the scale of machines that would otherwise be required
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Mixing and granulation in one step and in the shortest possible time
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Introduction of instruments for 100% in-line quality control
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No more need to discard entire batches - low-quality product can be selectively rejected
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Realisation of experimental test plans in the shortest possible time
What is twin-screw pelletising and what role does it play in tablet production?
Twin-screw granulation is a fully continuous wet granulation process in which powder is mixed, kneaded and granulated simultaneously using two rotating screws. It is ideal as an introduction to continuous pharmaceutical production.
What are the advantages of the Twin-Screw Granulator BCG from L.B. Bohle?
The BCG enables extremely short dwell times (less than 1 minute), combines mixing and granulation in a single step and requires less GMP space than other machines thanks to its compact design. This saves space and costs while maintaining high efficiency.
How is product quality ensured?
By using PAT technologies such as NIR or Raman Spectroscopy and particle size analysis, quality can be monitored in real time. Inferior products are specifically rejected so that entire batches do not have to be discarded.
Can the BCG only be used individually or can it also be integrated?
The Twin-Screw Granulator can be operated as a stand-alone unit or fully integrated into the QbCon® continuous production line.
See for yourself and test our machines directly on site in our Service Centre and Technology Centre. Our competent and experienced team is at your disposal for test series or process optimisation in order totake your processes to a higher level. We offer you the opportunity to carry out practical tests to evaluate the efficiency, quality and Scalability of your processes. You benefit from state-of-the-art technology, comprehensive advice and customised support. Visit us and discover how our machines and processes can optimise your production processes and product quality.
Innovative technologies
As a technology leader for tablet production machines, we offer innovative solutions for every process step from development to large batches.
Customised solutions
L.B. Bohle develops and realises customised, highly complex machine solutions that are perfectly tailored to your requirements and production goals.
Support and customer service
L.B. Bohle is always at your side. With short response times and a clear focus on solutions, we are always reliably at your disposal - personally, competently and practically.
Sustainability
Sustainability is firmly anchored in all areas of the company. We make targeted investments in infrastructure and research to make our machines even more efficient and environmentally friendly.
High-tech pharmaceutical machinery "Made in Germany". With our extensive product portfolio, we optimise your pharmaceutical solids production. Find out more about the company now.
