Grinding and Sieving in the pharmaceutical industry

Grinding and Conical Sieves

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Grinding and Sieving process

Grinders and Conical Sieves are essential for precise, safe and valid production processes in the pharmaceutical, chemical and food industries. These machines play a central role in the pharmaceutical production of tablets in particular.

In tablet production, grinding machines ensure the targeted comminution of active ingredients and excipients, while Conical Sieves ensure the uniform distribution of Particle Sizes. A homogeneous particle size distribution is the basis for reproducible mixing processes, optimum flow properties and a consistently high quality of the end products.

Conical Sieves and grinding machines for the pharmaceutical industry thus enable stable, scalable and GMP-compliant production processes - from active ingredient preparation to the finished tablet.

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L.B. Bohle offers you a comprehensive range of state-of-the-art machines and systems for your tablet production. Individually tailored to your requirements, our machines optimise your production processes and ensure optimum quality. Our machine finder will guide you quickly and easily to the optimum solution for your processes.

With L.B. Bohle, you can achieve the highest production efficiency and maximum product quality.

Methods, processes and technologies in Grinding and Sieving technology

In pharmaceutical production, mills and Conical Sieves are indispensable technologies when it comes to the precise preparation of powders and granulates. They ensure reproducible processes, uniform particle distribution and thus create the basis for high-quality dosage forms.

Grinding and Conical Sieves are ideal for

  • filling and emptying process machines,
  • transferring products between containers
  • calibrating powders before further processing.

Surface enlargement

Mills or Hammer Mills increase the surface area of the particles. The comminution in the mill increases the surface area of the solids. This accelerates the dissolution rate and improves the bioavailability of Active Pharmaceutical Ingredients (API).

Particle homogenisation

Conical Sieves, on the other hand, ensure homogeneous mixing. The Conical Sieve helps to equalise Particle Sizes and ensures even distribution. Another crucial step before the mixing process.

Versatile application options

Thanks to their compact design and high flexibility, grinders and Conical Sieves can be seamlessly integrated into existing process lines. They can be quickly integrated into different production environments.

Requirements for the technology of pharmaceutical Grinding and Sieving

Grinding and Conical Sieves ensure quality in the pharmaceutical manufacturing process by crushing agglomerates, homogenising Particle Sizes or classifying fine powders.

Areas of application for Grinding and Conical Sieves

Grinding and Conical Sieves are used in various production scenarios in the food, chemical and pharmaceutical industries, depending on the application and type.

Grinding and Conical Sieves are used for everything from research & development to large-volume production. A wide variety of materials are processed reliably and efficiently. The BTM Hammer Mill, the BTS screening system and the BRS rotary screen are ideal for use in continuous or batch production, research and product development.

Grinding and Conical Sieves are used in the production of Active Pharmaceutical Ingredients (API) and Excipients, the pulverisation of pharmaceuticals and to achieve the optimum particle size distribution.

Homogenisation of powder mixtures

A homogeneous mixture is required for an even distribution of the Active Pharmaceutical Ingredient (API) in the subsequent tablet or capsule. Conical Sieves contribute to this by levelling particle sizes and ensuring consistent particle distribution. This improves miscibility and ensures a consistent concentration of active ingredient in the end product.

Calibration after granulation

After processes such as Wet Granulation or subsequent drying, the granulate needs to be calibrated. Conical Sieves bring the granulate to a uniform particle size that is ideal for further processing in the Tableting machine. This ensures uniform dosing and pressability .

Remilling of defective batches

Not every tablet produced immediately fulfils all quality criteria. Deviations in weight, hardness or appearance can lead to individual batches having to be discarded. With the help of grinding machines,however, thesedefective tablets can be crushed and reintroduced into the production process. Remilling reduces waste and increases resource efficiency.

Batch Production or Continuous Manufacturing

Whether in the classic batch process or in continuous production processes. Grinding and Conical Sieves can be used flexibly and can be seamlessly integrated into production lines.

Grinding and Sieving with the Hammer Mill or Conical Sieves from L.B. Bohle

For the pharmaceutical industry, L.B. Bohle offers flexible, economical and resource-saving technology solutions for Grinding and Sieving that optimise the production process. The product range includes laboratory and production-scale systems that enable a wide range of options and product extensions to ensure an efficient and sustainable mixing process.

Make an enquiry now

Do you have any questions about our machines, services or solutions? Our team will be happy to help you! Get in touch with us. We will advise you individually and work with you to find the best solution for your requirements. We look forward to your enquiry!

Burkhard Schmidt

Sales Director

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