Mixing systems are indispensable for precise, homogeneous and valid production processes in the pharmaceutical, chemical and food industries. In the pharmaceutical industry, the mixing process is one of the most relevant processes for the commercial production of medicines and pharmaceuticals.
In tablet production, mixing systems ensure the homogeneity of the mixture of different solids. A similar particle size and particle size distribution are the premise for the miscibility of solids. For this reason, the Grinding or sieving process usually precedes the mixing process.
The homogeneous mixing of powders, active ingredients and excipients must be guaranteed in terms of safety and hygiene. Mixing systems from L.B. Bohle help production staff in tablet manufacturing to carry out the process smoothly and precisely. Good Manufacturing Practices (GMP) are thus implemented right from the start.
L.B. Bohle is valued by customers worldwide for the versatility of its mixing systems. With its broad portfolio and container capacities of up to 12,000 litres, the mixing system specialist offers the optimum solution for every production challenge. The mixing systems therefore provide an efficient and reliable basis for the subsequent production process.
Mixing systems ensure thatactive ingredients and excipients aremixed particularly gently and homogeneously. The pharmaceutical industry generally relies on stationary mixers for tablet production. Mobile mixers, often smaller devices, are mainly used in research and product development or for small batches.
Automation
The integration of mixers or mixing systems into higher-level control systemsenables seamless Documentation and control of every process step. Filling quantities are precisely monitored and controlled using integrated weighing systems, which also increases product safety.
GMP compliance and Validation
Compounding systems must comply with Good Manufacturing Practice (GMP). The GMP standard ensures that medicinal products and Active Pharmaceutical Ingredients (APIs) are produced with consistent quality. Mixer validation ensures that the mixing process fulfils the required quality standards. Validation is a decisive criterion for ensuring the quality and consistency of products in the chemical, food and pharmaceutical industries.
Hygienic design and cleaning
The decisive factor is the simple, fast and complete possibility of cleaning the materials, surfaces and structural elements. L.B. Bohle favours round containers for its mixing systems. Their smooth and cornerless surfaces prevent the accumulation of dirt - in contrast to square containers - and enable complete and efficient cleaning. This is a decisive factor, especially in the food, chemical and pharmaceutical industries.
The systems can optionally be equipped with CIP (Cleaning in Place) or WIP (Washing in Place) to further automate and standardise the cleaning process.
Scalability
Mixing systems for the pharmaceutical industry are designed to ensure a smooth Scale-up from laboratory to production scale. Batch sizes can thus be flexibly adapted.
Flexibility
Mixing systems are particularly flexible as they can accommodate mixing containers with different capacities. Mixing systems also offer the option of different pick-up systems. For example, systems with a standard load arm and clamp, mandrels on the lifting arm or a lifting arm with eccentric, power or hydraulic clamps can be used.
Thanks to their modular design, mixing systems can be customised to meet specific production requirements. Additional important production functions such as vacuum mixing or inertisation can be implemented.
The advantages of our Blending Systems
Homogeneous and gentle mixing: Safe and uniform mixing of active ingredients and excipients
GMP conformity and validatable processes: Reproducible quality and mixing quality thanks to validatable systems fulfil all the requirements of the pharmaceutical industry.
Hygienic design and easy cleaning: Round containers, smooth surfaces and optional WIP/CIP cleaning for efficient, residue-free cleaning and quick product changes.
Flexibility and Scalability: From Research & Development to large-scale production. Flexible use for different batch sizes and requirements.
Automation: Integration into existing control systems increases quality and efficiency and enables seamless Documentation and control.
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L.B. Bohle offers you a comprehensive range of state-of-the-art machines and systems for your tablet production. Individually tailored to your requirements, our machines optimise your production processes and ensure optimum quality. Our machine finder will guide you quickly and easily to the optimum solution for your processes.
With L.B. Bohle, you can achieve the highest production efficiency and maximum product quality.
