Fluidised bed system for the pharmaceutical industry
Fluidised bed system - BFS
With the patented Bohle Uni Cone BUC® process, L.B. Bohle improves fluidised bed technology. The specially designed inflow base with displacement cone ensures complete fluidisation and uniform, twin-free coating of particles and pellets.
More about the highlights
Fluidised bed systems have been used in the pharmaceutical industry for decades. By adding an aqueous or alcoholic granulation liquid, the mixture of primary dry powder particles is compacted. The liquid contains a volatile solvent that can be removed by drying. For a long time, the top spray process dominated fluidised bed systems. Recently, however, systems with tangential spray nozzles have increasingly demonstrated their advantages, so that the top-spray process is being replaced more and more. L.B. Bohle's range of fluidised bed granulation systems includes both R&D systems for small production quantities and systems for production scale.
With the Bohle Uni Cone BUC® process, L.B. Bohle is optimising the technology of fluidised bed processes. The patented Bohle Uni Cone BUC® is a specially slotted inflow base with a conically shaped displacement cone. This design enables complete fluidisation of the particles. The tangential particle movement ensures uniform fluidisation, e.g. of pellets, without twinning.
As the fluidised particles or granules are moved tangentially at a relatively low fluidisation height, a high expansion volume is not required. This reduces the installation height of the system. This saves costs and production space.
At least six filter elements of the BFS, which can be cleaned separately, ensure that the air flow through the product bed is not interrupted.
Another advantage of L.B. Bohle's tangential design is that granulation, coating and drying can be carried out in one system without the need for any modifications.
For the drying process, the BFS fluidised bed system can be equipped with an online moisture measurement system using NIR technology (similar to infrared analysis). This guarantees precise and reproducible determination of the current moisture content during the granulation and drying process.
Fluidised bed system BFS - The advantages
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Complete fluidisation of the particles
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Uniform filming, no twinning
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Integration of PAT, NIR and WIP
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Patented filter cleaning - patented diffuser
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Electrically driven filter lowering
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Easy removal of the inflow base
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Low installation height, more efficient use of space
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Pressure surge resistance of up to 12 bar - ideal for containment applications
| Series | Number of product filter bags | Height of fluidised bed system [mm] | Number of nozzles (tangential spray) | Control |
|---|---|---|---|---|
| BFS 30 | 4 | approx. 1980 | 1 | PLC-controlled, touch panel operation |
| BFS 60 | 6 | approx. 2930 | 2 | PLC-controlled, touch panel operation |
| BFS 180 | 6 | approx. 3600 | 3 | PLC-controlled, touch panel operation |
| BFS 240 | 8 | approx. 3920 | 4 | PLC-controlled, touch panel operation |
| BFS 360 | 12 | approx. 4570 | 5 | PLC-controlled, touch panel operation |
| BFS 480 | 10 | approx. 4990 | 6 | PLC-controlled, touch panel operation |
What makes the BFS fluidised bed system from L.B. Bohle so special?
The BFS system uses the patented Bohle Uni Cone BUC® technology, which enables complete fluidisation of the particles thanks to the slotted inflow base and displacement cone. This ensures uniform filming without twinning and eliminates the need for conversions between drying, granulating and coating.
What are the advantages of tangential spray technology compared to classic top spray systems?
Tangential systems require less fluidisation height and expansion volume, which reduces the installation height and space requirements of the system. This saves production space and costs, while at the same time offering more efficient and uniform particle processing.
How is Process Safety and quality ensured with the fluidised bed system BFS?
The unit is equipped with an NIR humidity measurement system for precise humidity monitoring. Separately cleaned filter elements prevent air flow interruptions, while the pressure shock-resistant design up to 12 bar offers optimum conditions for containment applications.
What practical advantages does the BFS offer in day-to-day operations?
Thanks to the electrically driven filter lowering, easy removal of the inflow base and integrated WIP system, the system is particularly easy to maintain and clean. The compact, space-saving design and ease of operation also ensure convenient and safe handling.
See for yourself and test our machines directly on site in our Service Centre and Technology Centre. Our competent and experienced team is at your disposal for test series or process optimisation in order totake your processes to a higher level. We offer you the opportunity to carry out practical tests to evaluate the efficiency, quality and Scalability of your processes. You benefit from state-of-the-art technology, comprehensive advice and customised support. Visit us and discover how our machines and processes can optimise your production processes and product quality.
Innovative technologies
As a technology leader for tablet production machines, we offer innovative solutions for every process step from development to large batches.
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L.B. Bohle develops and realises customised, highly complex machine solutions that are perfectly tailored to your requirements and production goals.
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