Granulation in the pharmaceutical industry

Granulation technologies and granulation machines

Find out more

Process for the production of granulates

Granulation (Latin granulum = granules) is one of the most relevant processes in the pharmaceutical industry for the commercial production of medicines and pharmaceuticals.

The aim of granulation is to produce granules that are used directly as medicines or as an intermediate product in the production of tablets or capsules. During granulation, coarser agglomerates are produced from fine powder. These can consist of solid and dry grains, whereby each grain represents an agglomerate of powder particles with sufficient strength. Compared to powders, granulates have better flow properties and can be filled or dosed more effectively, and no dust develops.

Find the ideal machine for your production now

L.B. Bohle offers you a comprehensive range of state-of-the-art machines and systems for your tablet production. Individually tailored to your requirements, our machines optimise your production processes and ensure optimum quality. Our machine finder will guide you quickly and easily to the optimum solution for your processes.

With L.B. Bohle, you can achieve the highest production efficiency and maximum product quality.

Methods, processes and technologies in granulation

In pharmaceutical granulation, various methods, processes and technologies are used to produce granules for capsules or tablets:

  • Fluidised bed granulation
  • High shear granulation
  • One-pot granulation
  • Twin screw granulation
  • Roller compaction / Dry Granulation

In the production of granulates, a distinction is made between Wet Granulation and Dry Granulation.

Areas of application for granulation

Granulation is an essential process step in pharmaceutical production. It enables improved flowability, dosing accuracy and uniform distribution of active ingredients, which means that granules can be used in a variety of ways in tablet and capsule production .

Capsule filling

Granules are also filled into capsules to achieve a controlled release of the Active Pharmaceutical Ingredient (API). Granulated formulations enable better handling and dosing.

Powder for inhalations

Granulation can be used to produce the powder for inhalation medication, adjusting the Particle Size to make it suitable for inhalation.

Immediately releasing formulations

Granulation is used to achieve rapid release of drugs by formulating the granules so that the Active Pharmaceutical Ingredient (API) is quickly available in the body.

Tablet production

Granulation is often used to improve the flowability and compressibility of powders. The formation of granules enables the production of tablets with a uniform dosage and stable structure.

Granulation with granulation systems from L.B. Bohle

For the pharmaceutical industry, L.B. Bohle offers flexible, economical and resource-saving technology solutions for Wet Granulation and Dry Granulation that optimise the production process. The product range includes laboratory and production-scale systems that enable a wide range of options and product extensions to ensure efficient and sustainable granulation.

Make an enquiry now

Do you have any questions about our machines, services or solutions? Our team will be happy to help you! Get in touch with us. We will advise you individually and work with you to find the best solution for your requirements. We look forward to your enquiry!

Burkhard Schmidt

Sales Director

Register once -
benefit several times

Register now and get access to White Papers, brochures and the L.B. Bohle newsletter!