Dry Granulation, also known as roller compaction, is a proven process for granulate production that is used primarily in the pharmaceutical industry, but also in other sectors (chemicals, food, food supplements). In contrast to Wet Granulation, Dry Granulation is characterised by the fact that it does not require the use of liquids.
In Dry Granulation, the granules are moulded/pressed directly from the powdery raw materials using mechanical pressure. As no liquids are added, the energy and cost-intensive drying process is not required. This makes Dry Granulation a particularly effective and economical solution, especially for raw materials that are sensitive to moisture or heat.
Dry Granulation also offers the possibility of specifically improving the physical properties of powders and adapting them to the requirements of further processing. Parameters such as flow properties, density, porosity and Particle Size are optimised. The process of continuous Dry Granulation combines compaction and the subsequent grinding step (Sieving / Calibration) to ensure a high-quality and homogeneous granulate for the subsequent production steps.
In addition to continuous Dry Granulation, as a stand-alone machine or integrated into continuous production, Dry Granulators from L.B. Bohle are also suitable for batch production.
However, batch production, with the separation between the production steps, is better suited to smaller quantities, which requires more time and resources than Dry Granulation in continuous production.
- Electromechanical drive without the use of oil guarantees stable compressibility and low energy consumption; can be used flexibly thanks to various Sieving setups (conical / oscillating)
- Effective WIP (Washing in Place) as standard
- Quick assembly / disassembly of the system in under 10 minutes (virtually tool-free)
- Simple integration into other systems (interlinked systems) or into Continuous Manufacturing systems
- Hygienic design for optimum Process Safety, easy cleaning and ergonomic operation
- Quick installation: flexible, mobile plug & play machine
- Reliability and durability reduce downtime and maintenance costs
- Transparent costs*
To ensure operator safety and the best possible product quality during Dry Granulation, L.B. Bohle offers suitable containment solutions. These are particularly indispensable when handling sensitive, hazardous and highly potent Active Pharmaceutical Ingredients (API). The aim is always to achieve an optimum balance between maximum safety, efficiency and costs.
The BRC series Dry Granulators not only offer comprehensive protection, but also options for a wide range of interfaces. In a customised application, the system is filled via a lifting column and a containment flap . The flaps are removed ergonomically and safely via a glove access with safety query. Product samples can also be taken at any time via two containment ports.
Dry Granulation is not only an indispensable process in the pharmaceutical production of tablets, capsules and other dosage forms, but has also proven itself in other industries. Dry Granulation is often the preferred method for large-volume or moisture-sensitive products in particular. It therefore also plays a central role in the processing and optimisation of powdered raw materials in the following industries.
Food & food supplement industry
Dry Granulation is used in the food industry and food supplement industry to process powdered raw materials, including sugar, starch, milk powder, instant drinks, soups, vitamins and minerals.
Chemical industry
The chemical industry uses Dry Granulation when powders with specific physical properties are required. Catalysts, fertilisers, dyes and pigments require specific granulations. Dry Granulation is used in the cosmetics industry to granulate raw materials such as face powder, blusher and eye shadow. These products are very sensitive to moisture.
Recycling industry
Dry Granulation is used in recycling and waste management to convert waste products such as metal powder into manageable granulates. In the production of cement, lime or gypsum, the building materials industry uses Dry Granulation to process the raw materials.
- Electromechanical drive without the use of oil guarantees stable compressibility and low energy consumption; can be used flexibly thanks to various Sieving setups (conical / oscillating)
- Effective WIP (Washing in Place) as standard
- Quick assembly / disassembly of the system in under 10 minutes (virtually tool-free)
- Simple integration into other systems (interlinked systems) or into Continuous Manufacturing systems
- Hygienic design for optimum Process Safety, easy cleaning and ergonomic operation
- Quick installation: flexible, mobile plug & play machine
- Reliability and durability reduce downtime and maintenance costs
- Transparent costs*
In contrast to Wet Granulation, which requires liquids, Dry Granulation does not use any solvents or water. This not only reduces process times, but also the risk of raw materials being adversely affected. Dry Granulation is also more environmentally friendly, as no solvents are used that need to be disposed of or recycled. Dry Granulation also eliminates the energy-intensive drying process.
L.B. Bohle offers technology-leading solutions for Dry Granulation and Wet Granulation. With its extensive expertise in the various processes, L.B. Bohle has the optimum system for every process. Whether you are dealing with large batches or development processes, we offer you the systems that will make your Dry Granulation or Wet Granulation more efficient and productive.
Advantages of Dry Granulation with L.B. Bohle
- lower material, labour and energy costs in Dry Granulation
- less space required and faster processes in Dry Granulation (less GMP space required, plug & play machine)
- Use of liquids and solvents only in Wet Granulation
- for Wet Granulation, the batch size must be adapted to the capacity of the machine - not for Dry Granulation
- less equipment required for dry granulation than for Wet Granulation
L.B. Bohle offers you a comprehensive range of state-of-the-art machines and systems for your tablet production. Individually tailored to your requirements, our machines optimise your production processes and ensure optimum quality. Our machine finder will guide you quickly and easily to the optimum solution for your processes.
With L.B. Bohle, you can achieve the highest production efficiency and maximum product quality.
